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COCOA POLYPHENOLS HEALTH EFFECTS – A RECAP
“Are polyphenols the only important constituent of cocoa?” No cocoa contains carbohydrates, fats, proteins, fiber, vitamins, minerals, methylxanthines and polyphenols. This is why cocoa is regarded as a functional food- provides health benefits beyond basic nutrition. Most of the health effects of cocoa-rich chocolate are due to the high content of nutritional polyphenols. In the last thirty years, polyphenols have attracted much interest owing to their antioxidant capacity (free radical scavenging and metal chelating ability) and their beneficial implications in human health, such as in the treatment and prevention of cancer and cardiovascular disease. Hence, cocoa has the health effects generally ascribed to polyphenol consumption.
Cocoa seeds contain many bioactive compounds including high levels of polyphenols (12–18% of dry weight) as well as fatty acids, vitamins, minerals, fiber, and several methylxanthine alkaloids(4% of dry weight), which are psychoactive dopaminergic substances such as caffeine, theobromine, theophylline, phenylethylamine, and paraxanthine.(Massaro et al. “Effect of Cocoa Products and Its Polyphenolic Constituents on Exercise Performance and Exercise-Induced Muscle Damage and Inflammation: A Review of Clinical Trials.” Nutrients 2019, 11, 1471; doi:10.3390/nu11071471). The compounds that show a significant correlation with the cardiometabolic health effects belong to the polyphenol class. Chemical data for dry seeds in the literature give a range of 6-18% of polyphenols, mainly composed of flavanols.
For many years, chocolate was consumed purely for pleasure, but in the last 20 years researches have shown that polyphenol-rich cocoa (dark chocolate with minimum 70% cocoa solids) and natural cocoa powder have beneficial effect on human health due to high content of polyphenols. Polyphenols are large and heterogeneous group of biologically active secondary metabolites in plants, where they act as cell wall support materials, colourful attractants for birds and insects, and defence mechanisms under different environmental stress conditions (wounding, infection, excessive light, or UV irradiation.
The most important food sources of polyphenols are vegetables and fruits, green and black tea, red wine, coffee, cocoa, olives, and some herbs and spices, as well as nuts and algae. But on weight basis cocoa is the richest source of polyphenols. Many researches have shown that polyphenols and/or polyphenol-rich foods have an important role in health preservation due to antioxidant properties. The antioxidant activity of cocoa was shown to be correlated with their polyphenol content.
Polyphenols can act as proton donor-scavenging radicals, inhibitors of enzymes that increase oxidative stress, chelate metals, bind carbohydrates, and proteins. These properties enable them to act as anticarcinogenic, anti-inflammatory, antihepatotoxic, antibacterial, antiviral, and antiallergenic compounds. This is supported by research of Hollenberg et al. who established relationship between high consumption of cocoa beverages and very low blood pressure levels, reduced frequency of myocardial infarction, stroke, diabetes mellitus, and cancer in Kuna Indians residing in archipelago on the Caribbean Coast of Panama. These health benefits were not seen in Kuna Indians residing on Mainland of Panama.
The fat in cocoa in the main is made up of oleic acid, palmitic acid, and stearic acid. Cocoa is also rich in minerals: potassium, phosphorus, copper, iron, zinc, and magnesium.
Polyphenols abundant in cocoa and dark chocolate, activate endothelial nitric oxide (NO) synthase; that leads to generation of NO,, which lowers blood pressure by promoting vasodilation. Indeed, following the consumption of polyphenol-rich, effects include improvement of the pulse wave speed and of the atherosclerotic score index, with parietal relaxation of large arteries and dilation of small and medium-sized peripheral arteries. . Once released, NO also activates the prostacyclin synthesis pathway, which acts as a vasodilator in synergy with NO, thereby contributing to thrombosis protection. Further, the anti-inflammatory and vasoprotective properties of prostacyclin are enhanced by its ability to reduce plasma leukotrienes (inflammatory mediators).
Cocoa plays also a role in treating cerebral conditions, such as stroke; in fact, cocoa intake is associated with increased cerebral blood flow. Polyphenol-rich cocoa has antiplatelet effects and thus of benefit in infarctive stroke treatment or prevention. Thus, daily polyphenol-rich consumption may reduce the likelihood of a stroke attack.
Cocoa and flavonols improve glucose homeostasis by slowing carbohydrate digestion and absorption in the gu. Indeed, cocoa extracts and procyanidins dose-dependently inhibit pancreatic α-amylase, pancreatic lipase, and secreted phospholipase A2. Cocoa and its flavonols improve insulin sensitivity by regulating glucose transport and insulin signaling proteins in insulin-sensitive tissues (liver, adipose tissue, and skeletal muscle).
The observed effects on glucose homeostasis is strongly dependent on the amount of polyphenols. In fact, a single-blind randomized placebo-controlled cross-over study showed, after 4 weeks, showed positive metabolic effects in subjects consuming polyphenol-rich cocoa. Therefore, the daily consumption of small quantities of flavonols from cocoa or chocolate, associated with a dietary intake of flavonoids, would constitute a natural and economic approach to prevent or potentially contribute to the treatment of type 2 diabetes with minimal toxicity and negative side effects.
There is strong interest in the effect of intestinal microbiota on health. Cocoa with its rich fiber content, polyphenol has impacted positively on gut health and in turn on overall metabolic and cardiovascular effects among others.
Studies have shown that cocoa has regulatory properties on the immune cells implicated in both innate (natural) and acquired immunity. Effects worth pursuing and promoting in light of COVID-19.
The polyphenol-rich cocoa acts on the central nervous system (CNS) and neurological functions through the production of NO. Vasodilation and increased cerebral blood flow provide oxygen and glucose to neurons, leading to increased formation of blood vessels in the hippocampus. The polyphenol-dependent antioxidant potential could contribute to the reduction of some neurodegenerative disorders. This inference is based on the fact that age-related cognitive impairment and disorders, such as Alzheimer’s and Parkinson’s diseases, are related to the accumulation of reactive oxygen species in the brain.
The effect of cocoa bioactives on signaling pathways in neurocytes may provide another support for linking it with regulation of brain function. Cocoa flavonols and methylxanthines can activate the cascade pathways of such molecules as rapamycin that play a crucial role in synaptic function, neuronal growth, memory mechanisms, and the pathogenesis of neurodegenerative disorders.
Polyphenol-rich cocoa exerts several effects on human sexuality, mainly acting as an aphrodisiac. Polyphenol-rich cocoa contains three unsaturated N-acylethanolamines, which, acting as cannabinoid mimics, could activate cannabinoid receptors or increase anandamide concentrations. These together with the methylxanthine components produce a transient feeling of well-being.
Until then daily/regularly consume polyphenol-rich cocoa
DR. EDWARD O. AMPORFUL
CHIEF PHARMACIST
COCOA CLINIC
Features
Monsieur’s daughter —(Part 2)
David rose and opened the door to the spare room. It was neat, as everything else in the house. He sank into the bed and stared at the ceiling. He had never hoped or expected his life to turn out that way.
Until some 12 hours ago, all seemed to be going well. He had already made a huge impact on his students, and the school. He was doing some extra-curricular work which was bringing in decent, regular income.
He had married a great looking, responsible young lady, and they had been blessed with a beautiful daughter. The future could only be bright.
Yet all that had come crashing down. Gladys had been having an affair with her ex-boyfriend, during her pregnancy when he came to Ghana briefly, and over the last few days, when he returned.
He confronted her with the evidence, and her denial was pathetic. It was over. He had pointed that out to her. Over the next hour he did a systematic review of the changes he would make.
The marriage was certainly over. And sadly, so was the Aboso SSS job. He would take a new major step in the next three months. As he was drifting off to sleep, his wife brought Sarah into the hall to breastfeed her. He woke up to rock her to sleep as usual, and went off to sleep.
The following morning, he left early for Agona Nkwanta, and informed his parents about the latest developments. They were devastated, but promised to back him in every steps he took. He got back to school during the first break and carried on with his work.
He stayed on at work till after seven, renewing application procedures for a Master’s Degree programme in Germany which he had deferred. When he got back home his wife’s parents were waiting. His father-in-law wasted no time to get to the point.
“My son, we came here with a simple, though difficult, task. Our daughter has confessed to us that she has offended you greviously. She went behind your back and had, er, an affair, with a young man with whom she was previously in a relationship. She admits that she was foolish.
She says that her actions do not reflect a lack of respect for you as her husband, or her love for you. We are on our knees, my son, pleading with you to have mercy on her, take her back into your arms and get on with your life as man and wife. I have great confidence in you, that a great future awaits you. I’m humbly asking for your forgiveness, my son.”
“You have spoken well, Daddy. I have great respect for you and Mummy. You have been very kind and helpful to me, since I met Gladys. I regret, however, that I cannot be reconciled to her.
You see, Gladys resumed the relationship with Simon when he returned to Ghana some months ago. She was spending time with him at the hotel at a time when, as far as I know, she was carrying my child. And since he returned to Ghana a few days ago, they have continued to spend time at the hotel.
So this is not a one-off thing. It is a relationship. I’m not going to say or do anything publicly, but the relationship is over. I will give her my fullest cooperation to give our daughter the best of care, but I will certainly move on with my life.”
“I have heard you, my son. Your reaction is both predictable and justified. Here’s what I will do. I will give you a little time to think about my humble petition, and I will pray that God himself will touch your heart to tamper justice with mercy, and save this marriage.”
After this, two delegations from Gladys’s family went to engage David’s family to plead for restoration of the marriage, but he was adamant. They continued to live in the flat, apparently as man and wife, but although he didn’t disclose his plans to her, she knew that he would eventually move out. One morning, as they were leaving for work, Gladys issued an emphatic threat.
“David, my parents and relatives have been to see you, and virtually fallen at your feet, begging you to forgive me for my mistake, and allow us to move forward as man and wife, and take care of Sarah.
But it appears that you are a perfect human being who does not make mistakes, and will, therefore, not forgive mistakes. Okay, you can take whatever step you want to take, but remember I also have an option. I will teach you a very bitter lesson, a lesson which you will never forget till you die.”
David smiled and eased himself out.
A couple of days later, David got home to find that Sarah was not around.
“Where’s Sarah?” he asked her.
“Ah, David” she said with mock politeness, “there’s something I need to tell you. You see, Sarah is not actually yours. She is Simon’s baby. I’m very sorry for misleading you. Really sorry. I’m sure that being a young man, you will be able to find a nice young woman who will give you children as beautiful as Sarah.”
David stood and stared at her for a very long time while she laughed herself into stitches. Then he stormed out and took a taxi to his parents’ house. After listening to him, his father told him his blunt, hard opinion.
“My son, I want you to brace yourself for a tough time. It is obvious Gladys wants to punish you for rejecting her. She must have thought out her plan well before coming out to tell you.
You may want us to report to the police, social welfare or what have you, but my feeling is that if you play her game, she will string you round her finger for a long time. Therefore, I think you should call her bluff. Ignore her, difficult as it may seem. No matter how long it takes, the child will come back to us.”
“Mama, what do you think?”
“I agree with your dad. Of course, there’s always the possibility that Sarah will actually be Simon’s, but it is highly unlikely. She has just connived with him to steal your child. Let’s ignore her. She will expect you to confront her and so on, but leave her alone.”
“I will do as you say, Mama and Dada, even though it is very difficult. I will ask her to move out of my house. I will stay the night, and go back to Aboso tomorrow morning.”
There was no evidence of Gladys when he got home. She had cleared the house of virtually everything. David replaced some basic stuff whilst focusing on his next move. He found a replacement teacher for the school, and resigned.
Although, he tried to leave quietly, the students, teachers and parents organised a party for him. There was great outpouring of grief as most people had learnt about the circumstances under which he was leaving. As a token of appreciation for his passion for work, the school authorities named the playground Monsieur Park after him. He left for Germany, promising himself to work hard to put the last bitter experience behind him.
By Ekow de Heel
Features
Migraines: Understanding the causes, symptoms, and treatment options
Migraines are a type of neurological disorder characterised by recurrent episodes of severe headaches, often accompanied by sensitivity to light, sound, and nausea.
According to the American Migraine Foundation, (AMF) over 39 million people in the United States suffer from migraines, with women being three times more likely to experience them than men.
In this article, we will delve into the causes, symptoms, and treatment options of migraines, as well as provide tips on how to manage and prevent them.
What are migraines?
Migraines are a complex neurological disorder that affects not only the brain but also the nervous system and blood vessels. During a migraine episode, the blood vessels in the brain expand, leading to inflammation and pain.
Symptoms of migraines
The symptoms of migraines can vary from person to person, but common symptoms include:
1. Severe headache: A throbbing or pulsating headache, usually on one side of the head.
2. Sensitivity to light and sound: Increased sensitivity to light, sound, and sometimes even touch.
3. Nausea and vomiting: Feeling queasy or vomiting, which can lead to dehydration.
4. Dizziness and vertigo: Feeling lightheaded or experiencing spinning sensations.
5. Aura symptoms: Some people experience aura symptoms, such as flashing lights, zigzag patterns, or numbness, before the headache begins.
Causes and triggers of migraines
While the exact cause of migraines is still unknown, research suggests that a combination of genetic, environmental, and hormonal factors contribute to their development. Common triggers of migraines include:
1. Genetics: Family history plays a significant role in migraine development.
2. Hormonal changes: Fluctuations in estrogen levels, such as during menstruation or menopause.
3. Stress: Physical or emotional stress can trigger migraines.
4. Sensory stimuli: Bright lights, loud noises, or strong smells.
5. Food and drink: Certain foods, such as aged cheeses, citrus fruits, or foods containing MSG or tyramine.
6. Sleep patterns: Changes in sleep patterns, such as insomnia or oversleeping.
7. Environmental factors: Changes in weather, altitude, or exposure to chemicals.
Treatment and management options
While there is no cure for migraines, various treatment options can help alleviate symptoms and prevent future episodes. These include:
1. Medications: Over-the-counter pain relievers, such as ibuprofen or acetaminophen, or prescription medications, such as triptans or ergotamines.
2. Lifestyle changes: Maintaining a consistent sleep schedule, staying hydrated, and avoiding triggers.
3. Relaxation techniques: Stress-reducing activities, such as meditation, yoga, or deep breathing exercises.
4. Chiropractic care: Spinal manipulation and other chiropractic techniques may help alleviate migraine symptoms.
5. Alternative therapies: Acupuncture, massage, or herbal supplements, such as feverfew or butterbur.
Preventing migraines
While migraines can be unpredictable, there are steps you can take to reduce their frequency and severity:
1. Keep a headache diary: Tracking your migraines can help you identify patterns and triggers.
2. Maintain a consistent sleep schedule: Irregular sleep patterns can trigger migraines.
3. Stay hydrated: Dehydration is a common migraine trigger.
4. Avoid triggers: Identify and avoid triggers, such as certain foods or sensory stimuli.
5. Manage stress: Engage in stress-reducing activities, such as meditation or yoga.
When to seek medical attention
While migraines can be debilitating, some symptoms require immediate medical attention:
1. Severe or frequent migraines: If you experience more than 15 headache days per month.
2. Increasing frequency or severity: If your migraines worsen over time.
3. Aura symptoms: If you experience aura symptoms, such as numbness, weakness, or difficulty speaking.
4. Headache with fever: If you have a headache accompanied by a fever, confusion, or stiff neck.
5. Recent head trauma: If you have experienced a recent head injury.
Conclusion
Migraines are a complex and debilitating neurological disorder that affects millions of people worldwide. While there is no cure, various treatment options and lifestyle changes can help alleviate symptoms and prevent future episodes.
By understanding the causes, symptoms, and treatment options of migraines, you can take control of your condition and improve your quality of life.
By Robert Ekow Grimmond Thompson