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Resynapsing …A paradigm shift in neural reorganisation and synaptic plasticity

Abstract:

Resynapsing, a novel concept in neuroscience, refers to the dynamic reorganisation of neural con­nections and synaptic strength in response to experience, learning, and environmental factors.

This article provides a com­prehensive overview of the theoretical frameworks, neu­robiological mechanisms, and technical approaches underly­ing resynapsing, with a focus on the innovative techniques developed by Robert Grim­mond-Thompson, pioneer of Emotional Surgery and Emotion­al Elysium.

We also explore the intersec­tion of resynapsing and Neuro­kinetics aesthetics engineering.

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Introduction:

The human brain is a com­plex, dynamic system char­acterised by intricate neural networks and synaptic connec­tions.

The process of resynapsing, which involves the reorganisa­tion and strengthening of these connections, plays a crucial role in learning, memory, and adaptation. Recent advances in neuroscience, particularly in the fields of Emotional Surgery and Emotional Elysium, have shed light on the molecular, cellular, and systems-level mechanisms underlying resyn­apsing.

Theoretical Frameworks:

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Resynapsing can be under­stood within the context of several theoretical frameworks, including:

1. Hebbian Theory: “Neurons that fire together, wire togeth­er” (Hebb, 1949).

2. Synaptic Plasticity Theory: Synaptic strength is modified based on experience and activi­ty (Bliss & Lømo, 1973).

3. Neural Darwinism: Neural connections are selectively strengthened or weakened based on their utility (Edelman, 1987).

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Neurobiological Mecha­nisms:

Resynapsing involves a com­plex interplay between mul­tiple neurobiological mecha­nisms, including:

1. Synaptic potentiation: Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength.

2. Neural oscillations: Syn­chronised neural activity in dif­ferent frequency bands (e.g., alpha, beta, gamma).

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3. _Neurotransmitter modu­lation: Regulation of synaptic plasticity by neurotransmitters such as dopamine, serotonin, and acetylcholine.

Emotional Surgery and Emo­tional Elysium:

Robert Grimmond-Thomp­son’s pioneering work in Emo­tional Surgery and Emotional Elysium has revolutionised our understanding of resynapsing.

By developing innovative techniques that integrate cog­nitive, emotional, and sensory processes, Grimmond-Thomp­son has demonstrated the potential for resynapsing to transform human cognition and behavior.

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Neurokinetics Aesthetics Engineering:

The intersection of resynaps­ing and Neurokinetics aesthet­ics engineering offers exciting possibilities for the develop­ment of novel therapeutic approaches. By integrating principles from neuroscience, engineering, and aesthet­ics, Neurokinetics aesthetics engineering can provide new insights into the neural mecha­nisms underlying resynapsing.

Implications and Future Directions:

Resynapsing has significant implications for our under­standing of brain function, behavior, and neurological disorders. Future research directions include:

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1. Investigating the role of resynapsing in learning and memory.

2. Developing novel thera­peutic approaches for neurolog­ical and psychiatric disorders.

3. Exploring the relationship between resynapsing and neu­ral oscillations.

Conclusion:

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Resynapsing represents a paradigm shift in our under­standing of neural reorganisa­tion and synaptic plasticity. By elucidating the mechanisms and technical approaches underly­ing resynapsing, we can unlock new avenues for the diagnosis, treatment, and prevention of neurological and psychiatric disorders.

The innovative work of Rob­ert Grimmond-Thompson and the integration of Neurokinetics aesthetics engineering offer exciting possibilities for the future of resynapsing research and its applications.

References:

Bliss, T. V., & Lømo, T. (1973). Long-lasting potentia­tion of synaptic transmission in the dentate area of the anaes­thetized rabbit following stim­ulation of the perforant path. Journal of Physiology, 232(2), 331-356.

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Edelman, G. M. (1987). Neu­ral Darwinism: The theory of neuronal group selection. Basic Books.

Hebb, D. O. (1949). The orga­nization of behavior: A neuro­psychological theory. Wiley.

Grimmond-Thompson, R. (2020). Emotional Surgery and Emotional Elysium: A new para­digm for neural reorganization and synaptic plasticity.

Never become God’s enemy

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SINCE we are in a Christmas season, l am motivated to put on my preaching cap. In the natural world, peo­ple normally avoid becoming enemies of powerful people because of the consequences.

If people fear to deliberate­ly incur the wrath of influen­tial personalities, it beats my imagination why people would deliberately choose to antago­nise almighty God, the creator of heaven and earth and all the natural things we all see.

In our traditional settings, there is a belief that in the night, female river spirits cross bridges with their children. Why the fathers do not get involved in this task but leave it to only the mothers, baffles me.

Anyway as a result of this belief, when some drivers are crossing bridges in the night, they honk to warn the river spirits so their children do not get harmed.

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Ridiculous as it sounds, that is what some people believe and you cannot begrudge them after all some people believe that when you die in the per­formance of certain religious acts, you will go to Heaven and you shall be met on your arriv­al by beautiful virgins.

Ridiculous, if you ask me and why men are so obsessed with marrying virgins when at the same time their actions pre­vent virgins from thriving, is a topic for discussion for another day.

The Bible says in Deuteron­omy Chapter 4 the verse 24 that “For the Lord thy God is a consuming fire, even a jealous God” KJV. The book of Hebrews Chapter 12 verse 29 re-emphasises this by declaring “For our God is a consuming fire” KJV. This clearly shows us the other side of God’s nature.

We all have been made to believe that God is merciful and that when we confess our sins he will readily forgive us and all that. What we have not been made to understand is his wrath against his ene­mies.

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Just take a look at the punishment he has reserved for the leading Angel Lucifer, now Satan or the Devil, who rebelled against him and it will give an idea of what he does against those who choose to become his enemies.

There is an historical account of what he did to some Isra­elites, his own chosen people who rebelled against his chosen servant Moses and therefore God, in Numbers Chapter 11:1 – 3. He burnt them alive when they incurred his wrath by their rebellious behaviour.

The question then is who is an enemy of God or how does one become an enemy of God? Proverbs give us an indication of how one can become the enemy of God. Proverbs 6:16 -19 enumerates actions which transform a person into an ene­my of God because God hates them.

These include lying, display of pride, character assassina­tion etc. which are rife in our society. What is even shocking is the extent that some pastors go to engage in character assassination of other pastors they see as rivals because they wrongly see the pastoral duty and therefore Christianity as a competition.

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Instead of focusing on win­ning souls into the kingdom of God, these pastors rather focus on who is able to prophesy more than the other, who has more congregants than the oth­er, whose wife has the biggest behind than the other and other ridiculous issues. Once pride sets into a person’s life, he or she becomes an enemy of God.

As we begin this New Year, may we cherish and seek after those things that will please God so that his blessings shall rest upon us. Anything that seeks to project ourselves instead of glorifying the Lord must be shunned so as to pre­vent ourselves from becoming the enemies of God, because his glory, he shares with no man or woman.

Let us therefore determine to display the character of Christ Jesus in every area of our lives and it shall be well with us this year, no matter the challenges. God bless.

By Laud Kissi-Mensah

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Monsieur’s daughter —(Part 2)

David  rose and opened the door to the spare room. It was neat, as everything else in the house. He sank into the bed and stared at the ceiling. He had never hoped or expected his life to turn out that way.

Until some 12 hours ago, all seemed to be going well. He had already made a huge impact on his students, and the school. He was doing some extra-curricular work which was bringing in decent, regular income.

He had married a great looking, responsible young lady, and they had been blessed with a beautiful daugh­ter. The future could only be bright.

Yet all that had come crashing down. Gladys had been having an af­fair with her ex-boyfriend, during her pregnancy when he came to Ghana briefly, and over the last few days, when he returned.

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He confronted her with the evi­dence, and her denial was pathetic. It was over. He had pointed that out to her. Over the next hour he did a systematic review of the changes he would make.

The marriage was certainly over. And sadly, so was the Aboso SSS job. He would take a new major step in the next three months. As he was drifting off to sleep, his wife brought Sarah into the hall to breastfeed her. He woke up to rock her to sleep as usual, and went off to sleep.

The following morning, he left ear­ly for Agona Nkwanta, and informed his parents about the latest devel­opments. They were devastated, but promised to back him in every steps he took. He got back to school during the first break and carried on with his work.

He stayed on at work till after sev­en, renewing application procedures for a Master’s Degree programme in Germany which he had deferred. When he got back home his wife’s parents were waiting. His father-in-law wasted no time to get to the point.

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“My son, we came here with a simple, though difficult, task. Our daughter has confessed to us that she has offended you greviously. She went behind your back and had, er, an affair, with a young man with whom she was previously in a rela­tionship. She admits that she was foolish.

She says that her actions do not reflect a lack of respect for you as her husband, or her love for you. We are on our knees, my son, pleading with you to have mercy on her, take her back into your arms and get on with your life as man and wife. I have great confidence in you, that a great future awaits you. I’m humbly asking for your forgiveness, my son.”

“You have spoken well, Daddy. I have great respect for you and Mummy. You have been very kind and helpful to me, since I met Gladys. I regret, however, that I cannot be reconciled to her.

You see, Gladys resumed the relationship with Simon when he returned to Ghana some months ago. She was spending time with him at the hotel at a time when, as far as I know, she was carrying my child. And since he returned to Ghana a few days ago, they have continued to spend time at the hotel.

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So this is not a one-off thing. It is a relationship. I’m not going to say or do anything publicly, but the relationship is over. I will give her my fullest cooperation to give our daughter the best of care, but I will certainly move on with my life.”

“I have heard you, my son. Your re­action is both predictable and justi­fied. Here’s what I will do. I will give you a little time to think about my humble petition, and I will pray that God himself will touch your heart to tamper justice with mercy, and save this marriage.”

After this, two delegations from Gladys’s family went to engage David’s family to plead for resto­ration of the marriage, but he was adamant. They continued to live in the flat, apparently as man and wife, but although he didn’t disclose his plans to her, she knew that he would eventually move out. One morning, as they were leaving for work, Gladys issued an emphatic threat.

“David, my parents and relatives have been to see you, and virtually fallen at your feet, begging you to forgive me for my mistake, and allow us to move forward as man and wife, and take care of Sarah.

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But it appears that you are a perfect human being who does not make mistakes, and will, therefore, not forgive mistakes. Okay, you can take whatever step you want to take, but remember I also have an option. I will teach you a very bitter lesson, a lesson which you will never forget till you die.”

David smiled and eased himself out.

A couple of days later, David got home to find that Sarah was not around.

“Where’s Sarah?” he asked her.

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“Ah, David” she said with mock politeness, “there’s something I need to tell you. You see, Sarah is not actually yours. She is Simon’s baby. I’m very sorry for misleading you. Really sorry. I’m sure that being a young man, you will be able to find a nice young woman who will give you children as beautiful as Sarah.”

David stood and stared at her for a very long time while she laughed her­self into stitches. Then he stormed out and took a taxi to his parents’ house. After listening to him, his fa­ther told him his blunt, hard opinion.

“My son, I want you to brace yourself for a tough time. It is obvi­ous Gladys wants to punish you for rejecting her. She must have thought out her plan well before coming out to tell you.

You may want us to report to the police, social welfare or what have you, but my feeling is that if you play her game, she will string you round her finger for a long time. Therefore, I think you should call her bluff. Ig­nore her, difficult as it may seem. No matter how long it takes, the child will come back to us.”

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“Mama, what do you think?”

“I agree with your dad. Of course, there’s always the possibility that Sarah will actually be Simon’s, but it is highly unlikely. She has just con­nived with him to steal your child. Let’s ignore her. She will expect you to confront her and so on, but leave her alone.”

“I will do as you say, Mama and Dada, even though it is very diffi­cult. I will ask her to move out of my house. I will stay the night, and go back to Aboso tomorrow morning.”

There was no evidence of Gladys when he got home. She had cleared the house of virtually everything. David replaced some basic stuff whilst focusing on his next move. He found a replacement teacher for the school, and resigned.

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Although, he tried to leave quietly, the students, teachers and parents organised a party for him. There was great outpouring of grief as most people had learnt about the circum­stances under which he was leaving. As a token of appreciation for his passion for work, the school authori­ties named the playground Monsieur Park after him. He left for Germany, promising himself to work hard to put the last bitter experience behind him.

By Ekow de Heel

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 Migraines: Understanding the causes, symptoms, and treatment options

 Migraines are a type of neurological disor­der characterised by recurrent episodes of severe headaches, often accompanied by sensitivity to light, sound, and nausea.

According to the American Migraine Foundation, (AMF) over 39 million people in the United States suffer from migraines, with women being three times more likely to ex­perience them than men.

In this article, we will delve into the causes, symptoms, and treatment options of migraines, as well as provide tips on how to manage and prevent them.

What are migraines?

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Migraines are a complex neu­rological disorder that affects not only the brain but also the nervous system and blood ves­sels. During a migraine episode, the blood vessels in the brain expand, leading to inflamma­tion and pain.

Symptoms of migraines

The symptoms of migraines can vary from person to person, but common symptoms include:

1. Severe headache: A throb­bing or pulsating headache, usually on one side of the head.

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2. Sensitivity to light and sound: Increased sensitivity to light, sound, and sometimes even touch.

3. Nausea and vomiting: Feel­ing queasy or vomiting, which can lead to dehydration.

4. Dizziness and vertigo: Feeling lightheaded or experi­encing spinning sensations.

5. Aura symptoms: Some peo­ple experience aura symptoms, such as flashing lights, zigzag patterns, or numbness, before the headache begins.

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Causes and triggers of mi­graines

While the exact cause of migraines is still unknown, re­search suggests that a combina­tion of genetic, environmental, and hormonal factors con­tribute to their development. Common triggers of migraines include:

1. Genetics: Family history plays a significant role in mi­graine development.

2. Hormonal changes: Fluc­tuations in estrogen levels, such as during menstruation or menopause.

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3. Stress: Physical or emo­tional stress can trigger mi­graines.

4. Sensory stimuli: Bright lights, loud noises, or strong smells.

5. Food and drink: Certain foods, such as aged cheeses, citrus fruits, or foods contain­ing MSG or tyramine.

6. Sleep patterns: Changes in sleep patterns, such as insom­nia or oversleeping.

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7. Environmental factors: Changes in weather, altitude, or exposure to chemicals.

Treatment and management options

While there is no cure for migraines, various treatment options can help alleviate symptoms and prevent future episodes. These include:

1. Medications: Over-the-counter pain relievers, such as ibuprofen or acetaminophen, or prescription medications, such as triptans or ergotamines.

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2. Lifestyle changes: Main­taining a consistent sleep schedule, staying hydrated, and avoiding triggers.

3. Relaxation techniques: Stress-reducing activities, such as meditation, yoga, or deep breathing exercises.

4. Chiropractic care: Spinal manipulation and other chiro­practic techniques may help alleviate migraine symptoms.

5. Alternative therapies: Acu­puncture, massage, or herbal supplements, such as feverfew or butterbur.

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Preventing migraines

While migraines can be unpredictable, there are steps you can take to reduce their frequency and severity:

1. Keep a headache diary: Tracking your migraines can help you identify patterns and triggers.

2. Maintain a consistent sleep schedule: Irregular sleep pat­terns can trigger migraines.

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3. Stay hydrated: Dehydra­tion is a common migraine trigger.

4. Avoid triggers: Identify and avoid triggers, such as certain foods or sensory stimuli.

5. Manage stress: Engage in stress-reducing activities, such as meditation or yoga.

When to seek medical at­tention

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While migraines can be debil­itating, some symptoms require immediate medical attention:

1. Severe or frequent mi­graines: If you experience more than 15 headache days per month.

2. Increasing frequency or se­verity: If your migraines worsen over time.

3. Aura symptoms: If you experience aura symptoms, such as numbness, weakness, or difficulty speaking.

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4. Headache with fever: If you have a headache accompa­nied by a fever, confusion, or stiff neck.

5. Recent head trauma: If you have experienced a recent head injury.

Conclusion

Migraines are a complex and debilitating neurological disorder that affects millions of people worldwide. While there is no cure, various treatment options and lifestyle changes can help alleviate symptoms and prevent future episodes.

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By understanding the causes, symptoms, and treatment op­tions of migraines, you can take control of your condition and improve your quality of life.

By Robert Ekow Grimmond Thompson

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